In two days of action, Australia's cricketers could achieve a feat which has eluded them for two years.
Not since January 2017 have the Australians triumphed in a one-day international series.
Victory on Tuesday against India in game two of the three-match series will snap a six-series losing streak in ODIs for Australia.
"It would mean a lot - it has been a while,'" Australia's vice-captain Alex Carey told reporters on Monday.
"As a cricket lover, I want to see Australia winning. And being a part of it, it means so much to us every game we play.
"So the series win would be a great result and a really big confidence booster."
Not since a 4-1 thumping of Pakistan in January 2017 has Australia collected an ODI series trophy.
Since then, the Australians have won just four of 26 ODIs - a stretch featuring 19 losses and three no-results.
But Carey said Australia's collective eyes weren't on the prize of a series win against the Indians but rather the "process" ahead of a World Cup captain starting in late May.
"To continue to get better every game is probably our biggest process at the moment leading into that World Cup," he said.
"Not thinking too far ahead, bringing it back to tomorrow night, but if we're playing the cricket we know we're good enough to play, the results will probably look after themselves."