The region takes in Benalla, Seymour, Wallan, Mansfield and Shepparton policing districts.
The 22 drivers caught came from 4378 preliminary breath tests conducted by police over the four-day police operation from midnight Thursday to midnight Monday.
Eastern Region Division Three Acting Senior Sergeant Tom Brown said a total of 300 offences – including speeding, mobile phone use and people not wearing seatbelts – were detected throughout the region in the first three days of Operation Regal.
Act Sen Sgt Brown said police were pleased with the courtesy shown by motorists, with only two serious injury collisions and no fatal accidents in the region during the operation.
He said he was generally pleased with the driving across the division.
Of the speeding offences that were detected, Act Sen Sgt Brown said there were not any significant ones.
He was still concerned that people were still drink or drug driving.
“It (22 people caught) tells me they’re still out there which is a concern,” he said.
“If you take the risk to take drugs and drive, we will catch you.”
With school holidays coming up soon, Act Sen Sgt Brown urged people to start checks on their vehicles now – making sure their tyres are good and their brakes are working correctly.
He also urged those with caravans to unsure they are following weight requirements for their van.
Act Sen Sgt Brown said drivers should ensure they don’t do over their gross weight for their van – which is the weight of the van and all of the belongings in it.
“If you overload, it’s an offence, but more importantly you are putting yours and your family’s safety at risk, Act Sen Sgt Brown said.
“It (overloading) is not hard to do by the time you put in food, clothes and pots and pans, but you need to keep an eye on it.”