An emergency warning has been issued for the southwest region, including Hester, Hester Brooke and Bridgetown in the Shire of Bridgetown-Greenbushes, Emergency WA said.
"You are in danger and need to act immediately to survive. There is a threat to lives and homes."
The out-of-control fire is fast-moving and is tracking southeasterly.
Locals have been warned it is too dangerous to return to their houses.
An emergency warning remains in place for the coastal town of Denmark, after residents were told to evacuate the town on Friday.
People living in nearby of Shadforth, William Bay, Scottsdale, Parryville, Ocean Beach, Kentdale and Kordabup should evacuate the area immediately if they have not done so.
"Variable wind behaviour continues to bring unpredictable fire conditions to the area," WA Emergency said.
An evacuation centre has been set up as the basketball stadium in Manjimup, about three hours south of Perth.
People required to quarantine should make other arrangements. If this is not possible, they can still head to the centre and notify staff when they arrive.Â
Pets are not permitted at the centre unless they are assistance animals, but those unable to make other arrangements should make their way to the centre and follow directions.
WA Premier Mark McGowan on Saturday said multiple areas in the state continue to face "dangerous bushfire conditions with more hot weather forecast today and tomorrow".
The premier thanked firefighters for their efforts over the week, and urged the public to follow advice from Emergency WA.
A number of bushfire advice warnings are in place across the state, with WA Emergency warning there is no threat to lives of homes at this stage.
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