Officers intercepted a 2008 Toyota Prado on the Hume Hwy in Wangaratta about 3pm on Wednesday, April 22.
During a subsequent search of the vehicle, police allegedly located and seized approximately 33kg of methylamphetamine.
Police say the drugs, with a street value of $13 million, were hidden inside the vehicle.
A man and woman, both from Hillsdale in NSW, were arrested at the scene.
The 22-year-old man, who has been named as Cameron Love, was charged with traffick large commercial quantity of a drug of dependence.
He appeared before Wangaratta Magistrates’ Court on Friday, April 24.
The 24-year-old woman, Isabella Anderson, was charged with traffick large commercial quantity of a drug of dependence.
She also appeared before Wangaratta Magistrates’ Court on Friday, April 24.
Mr Love did not apply for for bail. Ms Anderson did, but her application was refused.
The pair will face court again on July 30.
Detective Inspector Jamie Walker, Major Drug Squad, said that combatting the impact of drugs on the community was a major focus of Victoria Police.
“We have zero tolerance for those bringing harm to our community by importing and trafficking drugs of any kind,” Det Insp Walker said.
“Our team has relentlessly tracked down offenders as part of this investigation and in turn have removed considerable quantities of drugs from the streets.
“Drugs are a major driver of crime — this investigation shows our ongoing commitment against the illicit substances trade within Victoria”.
Anyone with information on illicit drug activity is urged to contact Crime Stoppers on 1800 333 000 or submit a confidential report online at crimestoppersvic.com.au