The anti-immigration party has been polling above 40 per cent and is hoping to secure an unprecedented absolute majority of seats on Sunday in the state parliament in Magdeburg.
This would allow it to bypass the mainstream parties' infamous "firewall" against co-operation with the far right, catapulting the AfD and its charismatic lead candidate Ulrich Siegmund into government.
Polls have shown the conservative Christian Democrats (CDU) - who lead the existing three-party coalition in Saxony-Anhalt - in a distant second place to the AfD, which has benefited from widespread dissatisfaction with Chancellor Friedrich Merz's government in Berlin.
Whether the AfD can secure a governing majority will likely hinge on whether a trio of left-wing parties - The Left, the Social Democrats (SPD) and the Greens - pass the five per cent threshold needed to win seats.
The AfD's rise in the polls has come even as its branch in Saxony-Anhalt is under surveillance by intelligence services due to its "confirmed" extremist views.
The party's manifesto includes setting up a task force to speed up deportations, reviving school exchanges with Russia, creating segregated classes for the children of asylum-seekers and banning rainbow flags in schools.
An outright victory for the AfD would make the 35-year-old Siegmund the youngest state premier in Germany's history.
It would also send shockwaves through the national political scene, with the party already leading in polls ahead of the next federal election, due to be held in 2029.
The prospect is a nightmare for Merz, who once famously pledged to halve the far-right party's popularity.
