The two-week long nationwide protests, which began in late December over an economic crisis marked by soaring inflation and rising living costs, have abated after a bloody crackdown by the clerical authorities that US-based rights group HRANA says has killed at least 6563, including 6170 protesters and 214 security forces.
Iranian Foreign Minister Abbas Araqchi told CNN Turk that 3100, including 2,000 security forces, had been killed.
The US, Israeli and European leaders tried to "provoke, create division, and supplied resources, drawing some innocent people into this movement," Pezeshkian said in a live state TV broadcast.
US President Donald Trump has repeatedly voiced support for the demonstrators, saying the US was prepared to take action if Iran continued to kill protesters. US officials said on Friday that Trump was reviewing his options but had not decided whether to strike Iran.
Israel's Ynet news website said on Friday that a US Navy destroyer had docked at the Israeli port of Eilat.
Trump, Israeli Prime Minister Benjamin Netanyahu and Europeans "rode on our problems, provoked, and were seeking - and still seek - to fragment society," Pezeshkian said.
"They brought them into the streets and wanted, as they said, to tear this country apart, to sow conflict and hatred among the people and create division," he said.
"Everyone knows that the issue was not just a social protest," he added.
Regional allies including Turkey, the United Arab Emirates, and Saudi Arabia have been engaging in diplomatic efforts to prevent a military confrontation between Washington and Tehran.
The US is demanding that Iran curb its missile programme if the two nations are to instead resume talks, but Iran has rejected that demand.
Foreign Minister Araqchi said in Turkey on Tuesday that missiles would never be the subject of any negotiations.
In response to US threats of military action, Araqchi said Tehran was ready for either negotiations or warfare, and also ready to engage with regional countries to promote stability and peace.
"Regime change is a complete fantasy. Some have fallen for this illusion," Araqchi told CNN Turk.
"Our system is so deeply rooted and so firmly established that the comings and goings of individuals make no difference."
Trump said on Thursday he planned to speak with Iran, even as the US sent another warship to the Middle East and the Pentagon chief said the military would be ready to carry out whatever the president decided.
One of the main US demands as a condition for resuming talks with Iran is curbing its missile program, a senior Iranian official told Reuters last week.
