The latest actions were taken this week when Secretary of State Marco Rubio determined they were no longer eligible for either lawful permanent resident status or to enter the United States.
The steps follow a move late last year in which the visas of several diplomats and staffers at Iran's mission to the United Nations were also revoked.
In a statement on Saturday, the State Department said the niece and grand-niece of former Iranian Revolutionary Guard Corps chief Qassem Soleimani, who was killed in a US air strike near the Baghdad airport in 2020, had been arrested late Friday by immigration agents after Rubio revoked their green cards.
"Hamideh Soleimani Afshar and her daughter are now in the custody of US Immigration and Customs Enforcement," the statement said, adding that Afshar's husband has also been banned from entering the United States.
Afshar and her daughter had been living a "lavish lifestyle" in Los Angeles for many years while publicly supporting the Iranian government and anti-American attacks, according to the statement.
She is "an outspoken supporter of the Iranian regime who celebrated attacks on Americans and referred to our country as the 'Great Satan,'" Rubio said in a post on X.
"The Trump administration will not allow our country to become a home for foreign nationals who support anti-American terrorist regimes."
The Iranian mission to the UN had no comment Saturday.
Afshar and her daughter are the latest Iranians to have their legal status in the US rescinded by Rubio, who recently revoked the visas of Fatemeh Ardeshir-Larijani, an academic and the daughter of Iran's former national security adviser Ali Larijani, who was killed in a US-Israel air strike last month.
Her husband, Seyed Kalantar Motamedi, also had his visa revoked, the State Department said. Neither are still in the US.
In early December, well before the surge of anti-government protests in Iran and the start of the war, the State Department revoked or declined to renew visas of several Iranian diplomats, including the deputy ambassador, and staff at Iran's mission to the United Nations.
The department said Friday that action had been taken on December 4 but declined to comment further "for privacy and security reasons" except to note that it was unrelated to either the protests or the war.
