Burnham, who returned to Westminster earlier this month after winning a parliamentary seat, is the only declared candidate to take over from Starmer and could be installed in Downing Street within weeks.
Starmer announced last week he would step down, just two years after winning a huge parliamentary majority for Labour, as his popularity sank.
Burnham, who rose to prominence as mayor of Greater Manchester and has been dubbed the "King of the North", will use Monday's speech to make devolving power to regions and local communities his flagship proposal.
Burnham will set out plans to boost economic growth by giving regional mayors more control over social housing, welfare and post-16 education, according to The Times.
He will also commit to a 10-year mission to raise living standards through reindustrialisation, housing, infrastructure and reform of utilities.
The focus would be not just on who governs Britain, but on changing how it is governed, his office said.
He will set out how he plans to "lift Britain back up to where it should be" and provide the "circuit-breaker it needs", alongside a pledge to "buying British" in a bid to revive industry and in turn securing more "social value" in the form of work placements and apprenticeships.
If he takes office, Burnham will become Britain's seventh prime minister in a decade, with many in his party believing only he has the charisma and the vision to connect with voters and counter the rise of Nigel Farage's anti-immigration Reform UK party.
However, with Britain's economy struggling from the impact of the war in Ukraine and more recently the energy shock of the US conflict with Iran, the scope to make radical spending changes is limited.
Burnham has previously said the government should "get beyond this thing of being in hock to the bond markets" but later said his comments had been misrepresented. He has also stepped back from earlier calls for large-scale nationalisation or a near-term return to the European Union.
with AP
